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Brings you Adequan Canine – an exceptional medication designed to help manage degenerative joint disease and promote overall joint health in dogs. With our worldwide discreet delivery service, you can conveniently access the benefits of this outstanding solution from the comfort of your own home.

Key Features:

1. Joint Health Support: Adequan Canine is specifically formulated to support and maintain joint health in dogs. It is commonly used to manage degenerative joint disease, osteoarthritis, and other conditions that affect joint function. By promoting cartilage repair and reducing joint inflammation, Adequan Canine helps improve mobility and alleviate pain in dogs.
2. Effective Treatment Option: Adequan Canine is a trusted and effective treatment option recommended by veterinarians. It contains polysulfated glycosaminoglycan (PSGAG), which plays a crucial role in maintaining healthy joint cartilage and reducing joint degradation. Adequan Canine has been shown to provide significant benefits in improving joint function and quality of life for dogs.
3. Convenient Dosage and Administration: Adequan Canine is available in a convenient injectable form, ensuring accurate dosage and easy administration. Your veterinarian will determine the appropriate dosage and administration schedule based on your dog’s specific condition and needs. Adequan Canine is typically administered via intramuscular injection.
4. Discreet Worldwide Delivery: At equicurepharm, we prioritize your privacy. Your order of Adequan Canine will be securely packaged and delivered discreetly to your doorstep, no matter where you are in the world. We strive to provide you with a hassle-free and confidential shopping experience.

How to Use:

Adequan Canine should only be used under the guidance and supervision of a veterinarian. They will assess your dog’s specific joint health needs, determine the appropriate dosage, and provide detailed instructions for administration. Adequan Canine is typically administered via intramuscular injection, and your veterinarian will guide you on the proper technique.

Safety Information:

It is crucial to consult with a veterinarian before using Adequan Canine. They will evaluate your dog’s medical history, current medications, and any underlying conditions to ensure the safe and appropriate use of this medication. Adequan Canine may have certain contraindications and potential side effects, which your veterinarian will explain to you.

Support Your Dog’s Joint Health with Adequan Canine:

Promote your dog’s joint health and improve their mobility with Adequan Canine from equicurepharm. With our discreet worldwide delivery service, you can conveniently have this exceptional medication delivered right to your doorstep, ensuring utmost convenience and privacy.

Order your supply of Adequan Canine now and take a significant step towards supporting your dog’s joint health and enhancing their quality of life!

Adequan Canine (polysulfated gylcosaminogylcan) is an FDA-approved disease-modifying osteoarthritis drug (DMOAD) that inhibits cartilage loss in dog’s joints, and may help to:

• • Restore joint lubrication
  • Relieve inflammation
  • Renew the building blocks oh healthy cartilage

Because Adequan® (polysulfated glycosaminoglycan) is a prescription, water-based, intramuscular, polysulfated glycosaminoglycan (PSGAG) that helps prevent the cartilage in your dog’s joint from wearing away, It helps keep the cartilage healthy and intact, so that the bone in the joint cannot touch other bones. No other drug for arthritis can do that.

How does it work?

It is administered two times a week for four weeks, the drug is injected intramuscularly to ensure it reaches the critical parts of the joint. It goes to work in the joint in about two hours and stays in the joint for about three days.  With Adequan® Canine you should see signs of improvement within four weeks. Your dog may begin to act like the playful, active dog you remember.

Cautions

Adequan Canine should be used with caution in dogs with renal or hepatic impairment. Possible side effects (pain at injection site, diarrhea and abnormal bleeding) were mild, transient and self-limiting. Safety studies of PSGAG in breeding, pregnant or lactating dogs have not been conducted.

Know how to spot the early signs of arthritis and the risk factors

• • Observe your dog for signs of arthritis
  • Tell your vet about signs you’ve observed and/or your dog’s behavior changes
  • Follow your veterinarian’s treatment protocol
  • Ask for Adequan® Canine to slow the disease of arthritis
  • Take steps to maintain good joint health
  • Keep your veterinarian updated on your dog’s progress
  • Talk to your veterinarian about other ways to maintain good joint health

For Adequan Canine Dosage, see Product Label tab and discuss with your veterinarian.

Adequan Canine Storage

Store at 20° to 25°C (68° to 77°F) excursions permitted to 15° to 30°C (59° to 86°F) (See USP Controlled Room Temperature). Avoid prolonged exposure to temperatures ≥40°C (104°F).

Use within 28 days of first puncture and puncture a maximum of 10 times. Dispose of spent needles in accordance with all federal, state and local environmental laws.

Contraindications

Do not use in dogs showing hypersensitivity to PSGAG. PSGAG is a synthetic heparinoid; do not use in dogs with known or suspected bleeding disorders.

Precautions

The safe use of Adequan® Canine used in breeding, pregnant, or lactating dogs has not been evaluated. Use with caution in dogs with renal or hepatic impairment.

Adverse Reactions

In the clinical efficacy trial, 24 dogs were treated with Adequan® Canine twice weekly for 4 weeks. Possible adverse reactions were reported after 2.1% of the injections. These included transient pain at the injection site (1 incident), transient diarrhea (1 incident each in 2 dogs), and abnormal bleeding (1 incident). These effects were mild and self-limiting and did not require interruption of therapy.

Post Approval Experience (2014)

The following adverse events are based on voluntary, post-approval reporting. Not all adverse reactions are reported to FDA/CVM. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using these data. The signs reported are listed in decreasing order of reporting frequency.

• • Vomiting
  • Anorexia
  • Depression/lethargy
  • Diarrhea.
  • In some cases, death has been reported

To report suspected adverse drug events, contact Luitpold Pharmaceuticals, Inc. at 1-800- 458-0163. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/AnimalVeterinary/SafetyHealth.

Warnings

Not for use in humans. Keep this and all medications out of reach of children.

Efficacy

Efficacy of Adequan® Canine was demonstrated in two studies. A laboratory study using radiolabeled PSGAG established distribution of PSGAG into canine serum and synovial fluid following a single intramuscular injection of 2 mg/lb. A clinical field trial was conducted in dogs diagnosed with radiographically-confirmed traumatic and/or degenerative joint disease of 1 or 2 joints. Joints evaluated included hips, stifles, shoulders, hocks and elbows. Fifty-one dogs were randomly assigned to receive either Adequan® Canine at 2 mg/lb of body weight or 0.9% saline.

Both treatments were administered by intramuscular injection twice weekly for 4 weeks (8 injections total). Investigators administering treatment and evaluating the dogs were unaware of the treatment assignment. A total of 71 limbs in 51 dogs were evaluated. Of these, 35 limbs in 24 dogs were in the Adequan® Canine treated group. Each lame limb was scored for lameness at a walk, lameness at a trot, pain, range of motion, and functional disability. The scores for the individual parameters were combined to determine a total orthopedic score. At the end of the treatment period, dogs treated with Adequan® Canine showed a statistically significant improvement in range of motion and total orthopedic score over placebo treated control dogs.

Toxicity

In a subacute toxicity study, 32 adult beagle dogs (4 males and 4 females per treatment group) received either 0.9% saline solution or PSGAG at a dose of 5 mg, 15 mg, or 50 mg per kg of body weight (approximately 2.3, 6.8, or 22.7 mg/lb), via intramuscular injection twice weekly for13 weeks. PSGAG doses represent approximately 1X, 3X, and 10X the recommended dosage of2 mg/lb, and more than 3 times the recommended 4-week duration of treatment. Necropsies were performed 24 hours after the final treatment. During week 12, one dog in the 50 mg/kg dosage group developed a large hematoma at the injection site which necessitated euthanasia. No other mortalities occurred during the treatment period. Statistically significant changes in the 50 mg/kg group included increased prothrombin time, reduced platelet count, an increase in ALT and cholesterol, and increased liver and kidney weights. Increased cholesterol and kidney weights were also noted in the 15 mg/kg group. Microscopic lesions were noted in the liver (Kupffer cells containing eosinophilic foamy cytoplasm), kidneys (swollen, foamy cells in the proximal convoluted tubules), and lymph nodes (macrophages with eosinophilic foamy cytoplasm) in the15 mg/kg and 50 mg/kg groups. Intramuscular inflammation, hemorrhage, and degeneration were seen in all 3 PSGAG treated groups; the incidence and severity appeared dose related.

Adequan Canine Pharmacology

The specific mechanism of action of Adequan® in canine joints is not known. PSGAG is characterized as a “disease modifying osteoarthritis drug”. Experiments conducted invitro have shown PSGAG to inhibit certain catabolic enzymes which have increased activity in inflamed joints, and to enhance the activity of some anabolic enzymes. For example, PSGAG has been shown to significantly inhibit serine proteinases. Serine proteinases have been demonstrated to play a role in the Interleukin-l mediated degradation of cartilage proteoglycans and collagen. PSGAG is reported to be an inhibitor of Prostaglandin E2 (PGE2) synthesis. PGE2has been shown to increase the loss of proteoglycan from cartilage. PSGAG has been reported to inhibit some catabolic enzymes such as elastase, stromelysin, metalloproteases, cathepsin B1,and hyaluronidases, which degrade collagen, proteoglycans, and hyaluronic acid in degenerative joint disease. Anabolic effects studied include ability to stimulate the synthesis of protein, collagen, proteoglycans, and hyaluronic acid in various cells and tissues invitro. Cultured human and rabbit chondrocytes have shown increased synthesis of proteoglycan and hyaluronic acid in the presence of PSGAG. PSGAGs have shown a specific potentiating effect on hyaluronic acid synthesis by synovial membrane cells in vitro.

Absorption, distribution, metabolism, and excretion of PSGAG following intramuscular injection have been studied in several species, including rats, rabbits, humans, horses and dogs.

Studies in rabbits showed maximum blood concentrations of PSGAG following IM injection were reached between 20 to 40 minutes following injection, and that the drug was distributed to all tissues studied, including articular cartilage, synovial fluid, adrenals, thyroid, peritoneal fluid, lungs, eyes, spinal cord, kidneys, brain, liver, spleen, bone marrow, skin, and heart.

Following intramuscular injection of PSGAG in humans, the drug was found to be bound to serum proteins. PSGAG binds to both albumin and chi and beta-globulins and the extent of the binding is suggested to be 30 to 40%. Therefore, the drug may be present in both bound and free form in the bloodstream. Because of its relatively low molecular weight, the synovial membrane is not a significant barrier to distribution of PSGAG from the bloodstream to the synovial fluid. Distribution from the synovial fluid to the cartilage takes place by diffusion. In the articular cartilage the drug is deposited into the cartilage matrix.

Serum and synovial fluid distribution curves of PSGAG have been studied in dogs and appear similar to those found in humans and rabbits.

In rabbits, metabolism of PSGAG is reported to take place in the liver, spleen, and bone marrow. Metabolism may also occur in the kidneys. PSGAG administered intramuscularly and not protein bound or bound to other tissues is excreted primarily via the kidneys, with a small proportion excreted in the feces.  Adequan Canine